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abc88ABCC8 gene mutations were identified in 16 of the 59 patients (see, e.g., 600509.0021-600509.0026), including 8 patients with heterozygous de novo mutations. The other 8 patientsATP-binding cassette transporter sub-family C member 8 is a protein that in humans is encoded by the ABCC8 gene. [5] [6] ABCC8 orthologs [7] have been identified in all mammals for which